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NNRT-IN-4

CAT: 0013-GTR19262592-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262592-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NNRT-IN-4 (Compound 10p) is an inhibitor of non-nucleoside reverse transcriptase (NNRT) with an IC50 of 0.713 μM for HIV-1RT. It exhibits antiviral activity against both wild-type and mutant strains of HIV-1, with an EC50 ranging from 6 to 63 nM. NNRT-IN-4 shows weak inhibitory activity on hERG (IC50=25.9 μM) and CYP enzymes (IC50>50 μM) . In mice, NNRT-IN-4 demonstrates good tolerance and safety at 2 g/kg.
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Molecular Formula
C36H38N6O4
Storage Conditions
-20°C
Notes
For research use only.

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