UCB-5307

• Description :

  UCB-5307 is a potent TNF signaling inhibitor with a KD of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex[1].

• CAS Number :

  [1515887-44-1]

• UNSPSC :

  12352005

• Target :

  TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ucb-5307.html

• Purity :

  97.09

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OC(C1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2)C4=CC=NC=C4

• Molecular Formula :

  C22H21N3O

• Molecular Weight :

  343.42

• References & Citations :

  [1]O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10 (1) :5795.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TNFRSF5/CD40