UCB-J

CAT: 0804-HY-136873-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-136873-01Size:5 mg
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Description
UCB-J is a ligand for the synaptic vesicle protein 2A (SV2A) with a pIC50 of 8.2. UCB-J can be used as a PET tracer for SV2A to assist in the diagnosis of epilepsy research[1][2][3][4].
CAS Number
[2242957-52-2]
UNSPSC
12352005
Target
Synaptic Vesicle Proteins
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ucb-j.html
Purity
99.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C[C@@](C2=CC(F)=C(C(F)=C2)F)([H])CN1CC3=CC=NC=C3C
Molecular Formula
C17H15F3N2O
Molecular Weight
320.31
References & Citations
[1]Joël Mercier, et al. Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: opening avenues towards the first SV2A positron emission tomography (PET) ligands. ChemMedChem. 2014 Apr;9 (4) :693-8.|[2]Aline Delva, et al. Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson's Disease. Mov Disord. 2020 Aug 7.|[3]Nabeel B Nabulsi, et al. Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. J Nucl Med. 2016 May;57 (5) :777-84.|[4]Zhengxin Cai, et al. Synthesis and Preclinical Evaluation of an 18 F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [ 18 F]SynVesT-2. ACS Chem Neurosci. 2020 Feb 19;11 (4) :592-603.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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