AM-5308

• Description :

  AM-5308 is the inhibitor for KIF18A (IC50=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. AM-5308 activates mitotic checkpoints, regulates cell division processes, including chromosome segregation and spindle assembly. AM-5308 exhibits antitumor activity[1][2].

• UNSPSC :

  12352005

• Target :

  Kinesin; Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/am-5308.html

• Purity :

  99.15

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  C[C@@H](OCC1)CN1C2=NC(NC(C3=C(C=C(C=C3)NS(CCO)(=O)=O)N4CCC5(CC4)CC5)=O)=CC=C2

• Molecular Formula :

  C26H35N5O5S

• Molecular Weight :

  529.65

• References & Citations :

  [1]Marc Noel PAYTON, et al. Kif18a inhibitors for treatment of neoplastic diseases. WO2021211549A1.|[2]Payton M, et al., Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat Cancer. 2024 Jan;5 (1) :66-84.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2410796-89-1]