AM-5308

• Description:

  AM-5308 is the inhibitor for KIF18A (IC50=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. AM-5308 activates mitotic checkpoints, regulates cell division processes, including chromosome segregation and spindle assembly. AM-5308 exhibits antitumor activity[1][2].

• UNSPSC:

  12352005

• Target:

  Kinesin; Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/am-5308.html

• Purity:

  99.15

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  C[C@@H] (OCC1) CN1C2=NC (NC (C3=C (C=C (C=C3) NS (CCO) (=O) =O) N4CCC5 (CC4) CC5) =O) =CC=C2

• Molecular Formula:

  C26H35N5O5S

• Molecular Weight:

  529.65

• References & Citations:

  [1]Marc Noel PAYTON, et al. Kif18a inhibitors for treatment of neoplastic diseases. WO2021211549A1.|[2]Payton M, et al., Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat Cancer. 2024 Jan;5 (1) :66-84.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2410796-89-1