UCB-6876

• Description :

  UCB-6876 is a TNFα inhibitor. UCB-6876 can specifically bind to the asymmetric crystalline form of the TNF-α trimer, with a KD of 22 μM[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ucb-6876.html

• Purity :

  98.49

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  OCC1=NC2=C(N1CC3=CC(C)=CC=C3C)C=CC=C2

• Molecular Formula :

  C17H18N2O

• Molecular Weight :

  266.34

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13 (1) :90.|[2]O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10 (1) :5795.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [637324-45-9]