TBAJ-5307

• Description :

  TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria inhibitor that can target the FO-domain of the engine and preventing rotation and proton-translocation. TBAJ-5307 inhibits non-tuberculous mycobacteria in vitro and in vivo[1].

• CAS Number :

  [2332831-92-0]

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/tbaj-5307.html

• Solubility :

  10 mM in DMSO

• Smiles :

  BrC1=CC2=C(N=C(OC)C([C@@H](C3=CC=NC(OC)=C3OC)[C@](O)(C4=CC(OC)=NC(OC)=C4)CCN(C)C)=C2)C=C1

• Molecular Formula :

  C30H35BrN4O6

• Molecular Weight :

  627.53

• References & Citations :

  [1]Ragunathan P, et, al. High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against non-tuberculous mycobacteria in vitro and in vivo. J Biol Chem. 2024 Jan 2:105618.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported