UCB-9260

• Description :

  UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM[1].

• CAS Number :

  [1515888-53-5]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ucb-9260.html

• Purity :

  98.38

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  OC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C

• Molecular Formula :

  C26H25N5O

• Molecular Weight :

  423.51

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]O'Connell J, et al.Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.Nat Commun. 2019 Dec 19;10 (1) :5795.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported