NCX-530

• Description:

  NCX-530 is an Indomethacin (HY-14397) molecule chemically conjugated with a NO moiety. NCX-530 can release NO. NCX-530 can inhibit cancer cells proliferation and induce apoptosis. NCX-530 can be used for the researches of cancer and inflammation[1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  O=C(C1=CC=C(Cl)C=C1)N2C3=C(C=C(OC)C=C3)C(CC(OC4=CC(CO[N+]([O-])=O)=CC=C4)=O)=C2C

• Molecular Formula:

  C26H21ClN2O7

• Molecular Weight:

  508.91

• References & Citations:

  [1]Ragot T, et al. Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73. Thyroid Res. 2015 Aug 14;8:13.|[2]Takeuchi K, et al. Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals. Dig Dis Sci. 2001 Aug;46 (8) :1805-18.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [204268-63-3]