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WIZ degrader 1

CAT: 0013-GTR19236348-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19236348-01Size:25 mg
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Description
Compound 141 is a potent, small molecule WIZ degrader (AC50 = 2 nM) that induces fetal hemoglobin (HbF) expression (EC50 = 6 mM) . It serves as a valuable research tool for studying genetic blood disorders, such as sickle cell disease and beta-thalassemia, in both cellular and preclinical models.
CAS Number
2839552-68-8
Field of Research
Epigenetics & Chromatin
Smiles
C (C1=CC2=C (C=NN2C=C1) N3C (=O) NC (=O) CC3) [C@H]4C[C@H] (C) N (CC5CCC (F) (F) CC5) CC4
Molecular Formula
C25H33F2N5O2
Molecular Weight
473.56
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

WIZ degrader 1
CAS Number2839552-68-8
PubChem CID165128461
IUPAC Name1-[5-[[(2S,4R)-1-[(4,4-difluorocyclohexyl)methyl]-2-methylpiperidin-4-yl]methyl]pyrazolo[1,5-a]pyridin-3-yl]-1,3-diazinane-2,4-dione
Molecular FormulaC25H33F2N5O2
Molecular Weight473.6
XLogP3.3
Topological Polar Surface Area70
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity758
SMILES
C[C@H]1C[C@@H](CCN1CC2CCC(CC2)(F)F)CC3=CC4=C(C=NN4C=C3)N5CCC(=O)NC5=O
InChI
InChI=1S/C25H33F2N5O2/c1-17-12-19(4-9-30(17)16-18-2-7-25(26,27)8-3-18)13-20-5-11-32-21(14-20)22(15-28-32)31-10-6-23(33)29-24(31)34/h5,11,14-15,17-19H,2-4,6-10,12-13,16H2,1H3,(H,29,33,34)/t17-,19+/m0/s1
InChIKey
QWAVXZLEKWIWKO-PKOBYXMFSA-N
Chemical Structure
2D Structure
2D structure of WIZ degrader 1
CAS: 2839552-68-8
CID: 165128461
Formula: C25H33F2N5O2
MW: 473.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight473.6
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass473.26023164
Monoisotopic Mass473.26023164
Topological Polar Surface Area70 Ų
Heavy Atom Count34
Formal Charge0
Complexity758
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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