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WIZ degrader 8

CAT: 0013-GTR19249875-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249875-01Size:10 mg
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Description
WIZ degrader 8 (compound 10) is a potent and selective molecular glue that induces targeted degradation of the WIZ transcription factor. This action effectively upregulates fetal hemoglobin (HbF) expression, positioning it as a promising research tool for investigating therapeutic strategies for sickle cell disease in both cellular and animal models.
CAS Number
2879251-26-8
Field of Research
Epigenetics & Chromatin
Smiles
O=C1N (CC=2C1=CC=C (O[C@H]3CN (CC) C[C@H] (C) C3) C2) C4C (=O) NC (=O) CC4
Molecular Formula
C21H27N3O4
Molecular Weight
385.457
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

WIZ degrader 8
CAS Number2879251-26-8
PubChem CID166154125
IUPAC Name3-[6-[(3R,5R)-1-ethyl-5-methylpiperidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
Molecular FormulaC21H27N3O4
Molecular Weight385.5
XLogP1.5
Topological Polar Surface Area79
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity639
SMILES
CCN1C[C@@H](C[C@H](C1)OC2=CC3=C(C=C2)C(=O)N(C3)C4CCC(=O)NC4=O)C
InChI
InChI=1S/C21H27N3O4/c1-3-23-10-13(2)8-16(12-23)28-15-4-5-17-14(9-15)11-24(21(17)27)18-6-7-19(25)22-20(18)26/h4-5,9,13,16,18H,3,6-8,10-12H2,1-2H3,(H,22,25,26)/t13-,16-,18?/m1/s1
InChIKey
DADIMSMRMNXYMS-HZBOCPGUSA-N
Chemical Structure
2D Structure
2D structure of WIZ degrader 8
CAS: 2879251-26-8
CID: 166154125
Formula: C21H27N3O4
MW: 385.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight385.5
XLogP31.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass385.20015635
Monoisotopic Mass385.20015635
Topological Polar Surface Area79 Ų
Heavy Atom Count28
Formal Charge0
Complexity639
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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