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WIZ degrader 5

CAT: 0013-GTR19237740-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19237740-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WIZ degrader 5 is a potent small molecule that induces the degradation of WIZ protein, achieving up to 88.6% efficiency in 293T cells. It serves as a valuable research tool for studying sickle cell disease and related hemoglobinopathies in cellular models.
CAS Number
2879250-73-2
Smiles
O=C1N (CC=2C1=CC=C (O[C@H]3CN (CC) [C@@H] (C) CC3) C2) C4C (=O) NC (=O) CC4
Molecular Formula
C21H27N3O4
Molecular Weight
385.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

WIZ degrader 5
CAS Number2879250-73-2
PubChem CID166154255
IUPAC Name3-[6-[(3R,6S)-1-ethyl-6-methylpiperidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
Molecular FormulaC21H27N3O4
Molecular Weight385.5
XLogP1.5
Topological Polar Surface Area79
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity639
SMILES
CCN1C[C@@H](CC[C@@H]1C)OC2=CC3=C(C=C2)C(=O)N(C3)C4CCC(=O)NC4=O
InChI
InChI=1S/C21H27N3O4/c1-3-23-12-16(5-4-13(23)2)28-15-6-7-17-14(10-15)11-24(21(17)27)18-8-9-19(25)22-20(18)26/h6-7,10,13,16,18H,3-5,8-9,11-12H2,1-2H3,(H,22,25,26)/t13-,16+,18?/m0/s1
InChIKey
IHBGNCYMSRWSLK-NHSXVPOTSA-N
Chemical Structure
2D Structure
2D structure of WIZ degrader 5
CAS: 2879250-73-2
CID: 166154255
Formula: C21H27N3O4
MW: 385.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight385.5
XLogP31.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass385.20015635
Monoisotopic Mass385.20015635
Topological Polar Surface Area79 Ų
Heavy Atom Count28
Formal Charge0
Complexity639
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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