PROTAC SMARCA2/4-degrader-32

PROTAC SMARCA2/4-degrader-32

• CAS Number: 2568273-79-8
• UNSPSC Description: PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s 90 after 24 h of treatment[1].
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-4-degrader-32.html
• Smiles: NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@@H]6CC[C@@H](N7CCN(CC7)CC(N[C@@H](C(C)(C)C)C(N8[C@@H](C[C@H](C8)O)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O)CC6)C=N5)C(CC4)C3
• Molecular Weight: 1012.27
• References & Citations: [1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported