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MTX-23

CAT: 0013-GTR19220969-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19220969-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MTX-23 is a PROTAC degrader targeting the androgen receptor (AR), effectively eliminating both full-length (AR-FL) and splice variant (AR-V7) proteins. It demonstrates potent anti-proliferative and pro-apoptotic activity in prostate cancer cell models, making it a valuable tool for investigating AR-dependent signaling and resistance mechanisms in vitro.
CAS Number
2488296-74-6
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Smiles
O=C (NCCCCC (=O) N[C@@H] (C (C) (C) C) C (=O) N1[C@@H] (C[C@@H] (O) C1) C (=O) N[C@@H] (C) C2=CC=C (C=C2) C3=C (C) N=CS3) COC4=C (C=CC (F) =C4F) C5N=C (SC=5) N6CCOCC6
Molecular Formula
C43H53F2N7O7S2
Molecular Weight
882.05
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PROTAC AR-V7 degrader-2
CAS Number2488296-74-6
PubChem CID154612215
IUPAC Name(2S,4R)-1-[(2S)-2-[5-[[2-[2,3-difluoro-6-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenoxy]acetyl]amino]pentanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
Molecular FormulaC43H53F2N7O7S2
Molecular Weight882.1
XLogP5.3
Topological Polar Surface Area232
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count17
Heavy Atom Count61
Formal Charge0
Complexity1470
SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCNC(=O)COC4=C(C=CC(=C4F)F)C5=CSC(=N5)N6CCOCC6)O
InChI
InChI=1S/C43H53F2N7O7S2/c1-25(27-9-11-28(12-10-27)38-26(2)47-24-61-38)48-40(56)33-20-29(53)21-52(33)41(57)39(43(3,4)5)50-34(54)8-6-7-15-46-35(55)22-59-37-30(13-14-31(44)36(37)45)32-23-60-42(49-32)51-16-18-58-19-17-51/h9-14,23-25,29,33,39,53H,6-8,15-22H2,1-5H3,(H,46,55)(H,48,56)(H,50,54)/t25-,29+,33-,39+/m0/s1
InChIKey
JOZGICGAZBMCJF-JMSDHYLISA-N
Chemical Structure
2D Structure
2D structure of PROTAC AR-V7 degrader-2
CAS: 2488296-74-6
CID: 154612215
Formula: C43H53F2N7O7S2
MW: 882.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight882.1
XLogP35.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count17
Exact Mass881.34159573
Monoisotopic Mass881.34159573
Topological Polar Surface Area232 Ų
Heavy Atom Count61
Formal Charge0
Complexity1470
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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