HS-438

• UNSPSC Description:

  HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177). HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML)[1].

• Target Antigen:

  Apoptosis; Bcr-Abl

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hs-438.html

• Smiles:

  O=C(NCCO)NC1=NC2=CC=C(C=C2S1)C3=CC=CC=C3OC

• Molecular Weight:

  343.40

• References & Citations:

  [1]Yun SM, et al. HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia. Cancer Lett. 2014 Jun 28;348(1-2):50-60.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1430720-10-7