HS-438

• Description :

  HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177) . HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML) [1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Bcr-Abl

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hs-438.html

• Smiles :

  O=C(NCCO)NC1=NC2=CC=C(C=C2S1)C3=CC=CC=C3OC

• Molecular Formula :

  C17H17N3O3S

• Molecular Weight :

  343.40

• References & Citations :

  [1]Yun SM, et al. HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia. Cancer Lett. 2014 Jun 28;348 (1-2) :50-60.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1430720-10-7]