BMS-986187

• Description:

  BMS-986187 is an δ-opioid receptor-selective positive allosteric modulator (PAM) with an EC50 of 0.03 μM and a pKB of 6.02 (～1 μM) . BMS-986187 has no observable PAM activity at the μ-receptor (EC50=3 μM) [1].

• UNSPSC:

  12352005

• Target:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-986187.html

• Concentration:

  10mM

• Purity:

  99.66

• Solubility:

  DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CC1=C(C=CC=C1)COC2=CC=C(C=C2)C3C4=C(OC(CC(C)(C5)C)=C3C5=O)CC(C)(C)CC4=O

• Molecular Formula:

  C31H34O4

• Molecular Weight:

  470.60

• References & Citations:

  [1]Neil T Burford, et al. Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J Med Chem. 2015 May 28;58 (10) :4220-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  δ Opioid Receptor/DOR

• CAS Number:

  684238-37-7