BD-9136

CAT: 0804-HY-149878-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-149878-01Size:1 mg
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Description
BD-9136 is a potent and highly selective BRD4 PROTAC depressant. BD-9136 has low-nanomolar degradation potencies against BRD4 , and its degradation selectivity for BRD4 is 1000 times that of BRD2 and BRD3 proteins. BD-9136 has antitumor activity[1]. (Pink: Desmethyl-QCA276 (HY-44103) ; Black: 3- (2- (4-Methylpiperazin-1-yl) ethyl) azetidin-3-ol; Blue: Thalidomide-4-OH (HY-103596) )
CAS Number
[3037514-38-5]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bd-9136.html
Purity
98.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NN=C2COCC(C(CC3=CC=CC=C3)=C(S4)C#CC5=CN(N=C5)C6(CCN7CCN(CC7)C)CN(C8=C(C9=CC=C8)C(N(C9=O)C%10CCC(NC%10=O)=O)=O)C6)=C4N21
Molecular Formula
C44H44N10O5S
Molecular Weight
824.95
References & Citations
[1]Hu J, et al. Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity. J Med Chem. 2023 Jun 22;66 (12) :8222-8237.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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