BD-1047 (dihydrobromide)

• UNSPSC Description:

  BD-1047 (dihydrobromide) is a selective functional antagonist of sigma-1 receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia[1].

• Target Antigen:

  Sigma Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/BD-1047-dihydrobromide.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)

• Smiles:

  CN(C)CCN(CCC1=CC=C(Cl)C(Cl)=C1)C.[H]Br.[H]Br

• Molecular Weight:

  437.04

• References & Citations:

  [1]Skuza G, et al. Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity. Pharmacol Rep. 2006 Sep-Oct;58(5):626-635.|[2]Shimazawa M, et al. Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage. Exp Eye Res. 2015 Mar;132:64-72.|[3]Rogóz Z, et al. Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats. Pharmacol Rep. 2006 Jul-Aug;58(4):493-500.Cell Rep. 2023 Jan 31;42(1):112011.|Eur J Pharmacol. 2023 Mar 8;175647.|Int Immunopharmacol. 2023 Dec 22:127:111382.|Int Immunopharmacol. 2023 Feb 22;117:109907.|Mol Med. 2022 Aug 3;28(1):87.|Neural Regen Res. 2024 Apr 3.|Life Sci. 2020 Sep 15;257:118047.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  138356-21-5