BD-1008

• Description:

  BD-1008 is a nonselective σ receptor antagonist with Kis against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 has an extremely low affinity for the D2 receptor (Ki = 1112 nM) and dopamine transporter (DAT) (Ki > 10,000 nM) . BD-1008 significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 blocks the self-administration behavior of σ agonists.BD-1008 can be used for the study of addiction therapy that target the σ receptor[1][2][3].

• UNSPSC:

  12352005

• Target:

  Sigma Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bd-1008.html

• Purity:

  98.41

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  CN(CCC1=CC=C(Cl)C(Cl)=C1)CCN2CCCC2

• Molecular Formula:

  C15H22Cl2N2

• Molecular Weight:

  301.25

• References & Citations:

  [1]Staelens L, et al. In vivo evaluation of [ (123) I]-3- (4-iodobenzyl) -1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one: a presumed dopamine D4 receptor ligand for SPECT studies. Nucl Med Biol. 2005 Apr;32 (3) :293-9. |[2]Garcés-Ramírez L, et al. Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis. Biol Psychiatry. 2011 Feb 1;69 (3) :208-17.|[3]Hiranita T, et al. Stimulants as specific inducers of dopamine-independent σ agonist self-administration in rats. J Pharmacol Exp Ther. 2013 Oct;347 (1) :20-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Sigma 1 Receptor; Sigma 2 Receptor

• CAS Number:

  [138356-08-8]