BD-1008

CAT: 0804-HY-135608-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-135608-01Size:5 mg

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Description

BD-1008 is a nonselective σ receptor antagonist with Kis against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 has an extremely low affinity for the D2 receptor (Ki = 1112 nM) and dopamine transporter (DAT) (Ki > 10,000 nM) . BD-1008 significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 blocks the self-administration behavior of σ agonists.BD-1008 can be used for the study of addiction therapy that target the σ receptor[1][2][3].

CAS Number

[138356-08-8]

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bd-1008.html

Purity

98.41

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CN(CCC1=CC=C(Cl)C(Cl)=C1)CCN2CCCC2

Molecular Formula

C15H22Cl2N2

Molecular Weight

301.25

References & Citations

[1]Staelens L, et al. In vivo evaluation of [ (123) I]-3- (4-iodobenzyl) -1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one: a presumed dopamine D4 receptor ligand for SPECT studies. Nucl Med Biol. 2005 Apr;32 (3) :293-9. |[2]Garcés-Ramírez L, et al. Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis. Biol Psychiatry. 2011 Feb 1;69 (3) :208-17.|[3]Hiranita T, et al. Stimulants as specific inducers of dopamine-independent σ agonist self-administration in rats. J Pharmacol Exp Ther. 2013 Oct;347 (1) :20-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Sigma 1 Receptor; Sigma 2 Receptor

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Alternative Products

Catalog	Name
sc-203426A	BD 1008
M27463-01	BD 1008 dihydrobromide
530480	BD-1008 HBr
MBS5813352	BD 1008 Free Base
sc-217700	BD 1008-d5 Dihydrobromide
MBS3602249-01	PRN 1008
MBS3841052-01	SD 1008
BA2112-25	CWHM-1008
TP2953-01	CBP-1008
T35125	We 1008

BD-1008

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