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IR-1048

CAT: 0804-HY-D1450-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D1450-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IR-1048 is a nitroreductase (NTR) -responsive near-infrared fluorescence (NIR) /photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment, restoring strong near-infrared absorption and fluorescence emission (NIR II window), while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching, achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment[1][2].
CAS Number
155613-98-2
Product Name Alternative
S01448
UNSPSC
12171500
Hazard Statement
H315, H319
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ir-1048.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
[F-][B+3]([F-])([F-])[F-].ClC1=CC=C2C3=C(/C(N2CCCC)=C\C=C4C(Cl)=C(CCC\4)/C=C/C5=[N+](CCCC)C6=CC=C(Cl)C7=CC=CC5=C67)C=CC=C31
Molecular Formula
C40H38BCl3F4N2
Molecular Weight
739.91
Precautions
H315, H319
References & Citations
[1]Xiaoqing Meng, et al. Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy. Theranostics. 2018 Nov 15;8 (21) :6025-6034.|[2]Xiaoxu Kang, et al. Dual-Cascade Responsive Nanoparticles Enhance Pancreatic Cancer Therapy by Eliminating Tumor-Resident Intracellular Bacteria. Adv Mater. 2022 Dec;34 (49) :e2206765.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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