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J-1048

CAT: 0804-HY-149403Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149403Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].
CAS Number
2374772-60-6
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/j-1048.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(NC(CN2C=C(C3=CC4=NSN=C4C=C3)C(C5=CC=CC(C)=N5)=N2)=S)=CC=C1
Molecular Formula
C23H17FN6S2
Molecular Weight
460.55
References & Citations
[1]Yang HX, et al. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation. Bioorg Chem. 2023 Oct;139:106723.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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