J-1048

• Description :

  J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].

• UNSPSC :

  12352005

• Target :

  Anaplastic lymphoma kinase (ALK)

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/j-1048.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC(NC(CN2C=C(C3=CC4=NSN=C4C=C3)C(C5=CC=CC(C)=N5)=N2)=S)=CC=C1

• Molecular Formula :

  C23H17FN6S2

• Molecular Weight :

  460.55

• References & Citations :

  [1]Yang HX, et al. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation. Bioorg Chem. 2023 Oct;139:106723.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2374772-60-6]