IR-251

• UNSPSC Description:

  IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis[1].

• Target Antigen:

  Fluorescent Dye; Mitochondrial Metabolism; PPAR; Reactive Oxygen Species; β-catenin

• Type:

  Dye Reagents

• Related Pathways:

  Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Others;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ir-251.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1(C)C(/C=C/C2=C(Cl)/C(CCC2)=C/CC3N(CCCCCC(O/C(NC4CCCCC4)=N/C5CCCCC5)=O)C(C=CC=C6)=C6C3(C)C)=[N+](CC)C7=C1C=CC=C7.[Br-]

• Molecular Weight:

  886.48

• References & Citations:

  [1]Wang J, et al. A novel multifunctional mitochondrion-targeting NIR fluorophore probe inhibits tumour proliferation and metastasis through the PPAR纬/ROS/尾-catenin pathway. Eur J Med Chem. 2023 Oct 5;258:115435.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported