Ir-CA

• Description :

  Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces apoptosis and autophagy. Ir-CA initiates mitophagy and cell cycle arrest to kill Cisplatin (HY-17394) -resistant A549R cells. Ir-CA can effectively inhibit metastasis by inhibiting MMP-2/MMP-9[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Autophagy

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ir-ca.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=[N]3C=CC=C6)([C-]7=C(C=CC=C7)C8=[N]4C=CC=C8)[N]9=CC=C(CNC(/C=C/C%10=CC=CC=C%10)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

• Molecular Formula :

  C43H35F6IrN5OP

• Molecular Weight :

  974.95

• References & Citations :

  [1]Yang J, et al. Consolidating Organometallic Complex Ir-CA Empowers Mitochondria-Directed Chemotherapy against Resistant Cancer via Stemness and Metastasis Inhibition. Inorg Chem. 2024 Mar 7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2870682-93-0]