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Ir-CA

CAT: 0804-HY-162344Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-162344Size:1 Each
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Description
Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces apoptosis and autophagy. Ir-CA initiates mitophagy and cell cycle arrest to kill Cisplatin (HY-17394) -resistant A549R cells. Ir-CA can effectively inhibit metastasis by inhibiting MMP-2/MMP-9[1].
CAS Number
[2870682-93-0]
UNSPSC
12352005
Target
Apoptosis; Autophagy
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ir-ca.html
Solubility
10 mM in DMSO
Smiles
CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=[N]3C=CC=C6)([C-]7=C(C=CC=C7)C8=[N]4C=CC=C8)[N]9=CC=C(CNC(/C=C/C%10=CC=CC=C%10)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Molecular Formula
C43H35F6IrN5OP
Molecular Weight
974.95
References & Citations
[1]Yang J, et al. Consolidating Organometallic Complex Ir-CA Empowers Mitochondria-Directed Chemotherapy against Resistant Cancer via Stemness and Metastasis Inhibition. Inorg Chem. 2024 Mar 7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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