Ir-CA

• UNSPSC Description:

  Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces apoptosis and autophagy. Ir-CA initiates mitophagy and cell cycle arrest to kill Cisplatin (HY-17394)-resistant A549R cells. Ir-CA can effectively inhibit metastasis by inhibiting MMP-2/MMP-9[1].

• Target Antigen:

  Apoptosis; Autophagy

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ir-ca.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=[N]3C=CC=C6)([C-]7=C(C=CC=C7)C8=[N]4C=CC=C8)[N]9=CC=C(CNC(/C=C/C%10=CC=CC=C%10)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

• Molecular Weight:

  974.95

• References & Citations:

  [1]Yang J, et al. Consolidating Organometallic Complex Ir-CA Empowers Mitochondria-Directed Chemotherapy against Resistant Cancer via Stemness and Metastasis Inhibition. Inorg Chem. 2024 Mar 7.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2870682-93-0