IR-58

• UNSPSC Description:

  IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway[1].

• Target Antigen:

  Apoptosis; Autophagy

• Type:

  Dye Reagents

• Related Pathways:

  Apoptosis;Autophagy

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ir-58.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(CNC(CCCCCCCCCCN1C2=C(C(C)(C)/C1=C/C=C3C(Cl)=C(CCC/3)/C=C/C4=[N+](CCCCCCCCCCC(NCC(OC)=O)=O)C5=C(C4(C)C)C=CC=C5)C=CC=C2)=O)OC.[Br-]

• Molecular Weight:

  1046.65

• References & Citations:

  [1]Yinghui Huang, et al. Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44. Gut. 2018 Feb;67(2):307-319.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2374274-85-6