IR-58

• Description :

  IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS) -Akt-mTOR pathway[1].

• UNSPSC :

  12171500

• Target :

  Apoptosis; Autophagy

• Type :

  Dye Reagents

• Related Pathways :

  Apoptosis; Autophagy

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ir-58.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(CNC(CCCCCCCCCCN1C2=C(C(C)(C)/C1=C/C=C3C(Cl)=C(CCC/3)/C=C/C4=[N+](CCCCCCCCCCC(NCC(OC)=O)=O)C5=C(C4(C)C)C=CC=C5)C=CC=C2)=O)OC.[Br-]

• Molecular Formula :

  C58H82BrClN4O6

• Molecular Weight :

  1046.65

• References & Citations :

  [1]Yinghui Huang, et al. Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44. Gut. 2018 Feb;67 (2) :307-319.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported

• CAS Number :

  [2374274-85-6]