IR-58

CAT: 0804-HY-D2227Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-D2227Size:1 Each

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Description

IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS) -Akt-mTOR pathway[1].

CAS Number

2374274-85-6

UNSPSC

12171500

Target

Apoptosis; Autophagy

Type

Dye Reagents

Related Pathways

Apoptosis; Autophagy

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ir-58.html

Solubility

10 mM in DMSO

Smiles

O=C(CNC(CCCCCCCCCCN1C2=C(C(C)(C)/C1=C/C=C3C(Cl)=C(CCC/3)/C=C/C4=[N+](CCCCCCCCCCC(NCC(OC)=O)=O)C5=C(C4(C)C)C=CC=C5)C=CC=C2)=O)OC.[Br-]

Molecular Formula

C58H82BrClN4O6

Molecular Weight

1046.65

References & Citations

[1]Yinghui Huang, et al. Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44. Gut. 2018 Feb;67 (2) :307-319.

Shipping Conditions

Room temperature

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

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