U-83836E

CAT: 0804-HY-117762-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-117762-01Size:5 mg
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AVAILABILITY: InStock
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Description
U-83836E (PNU-83836E) is a compound with anti-inflammatory and antioxidant activities that reduces lung inflammation inhibiting oxidative stress and ROS production. U-83836E has shown potential for treating asthma and lung inflammation in animal models[1][2].
CAS Number
[137018-55-4]
Product Name Alternative
PNU-83836E
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/u-83836e.html
Purity
98.59
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC1=C(C)C(C)=C2C(CC[C@](C)(CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)O2)=C1C.Cl.Cl
Molecular Formula
C30H46Cl2N6O2
Molecular Weight
593.63
References & Citations
[1]Johnson H G, et al. Late phase bronchoconstriction and eosinophilia as well as methacholine hyperresponsiveness in Ascaris-sensitive rhesus monkeys were reversed by oral administration of U-83836E[J]. International archives of allergy and immunology, 1993, 100 (4) : 362-366.|[2]Camins A, et al. U-83836E prevents kainic acid-induced neuronal damage[J]. Naunyn-Schmiedeberg's archives of pharmacology, 1998, 357: 413-418.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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