EA-230

CAT: 0804-HY-106279-02Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-106279-02Size:10 mg

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Description

EA-230 is a synthetic oligopeptide originally derived from beta-human chorionic gonadotropin (beta-hCG) lysates. EA-230 has anti-inflammatory effects and can be used for the research of sepsis[1].

CAS Number

503844-09-5

UNSPSC

12352209

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ea-230.html

Purity

99.92

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(C)[C@@H](C(O)=O)NC(CNC([C@H](CCC(N)=O)NC([C@@H](N)C)=O)=O)=O

Molecular Formula

C15H27N5O6

Molecular Weight

373.40

References & Citations

[1]Gueler F, et al. A novel therapy to attenuate acute kidney injury and ischemic allograft damage after allogenic kidney transplantation in mice. PLoS One. 2015 Jan 24;10 (1) :e0115709.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

Phase 2

Chemical Information

Ea-230

EA-230 is under investigation in clinical trial NCT03145220 (Immunomodulation of EA-230 Following On-pump Coronary Artery Bypass Grafting (CABG)).

CAS Number	503844-09-5
PubChem CID	10133920
IUPAC Name	(2S)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-aminopropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-methylbutanoic acid
Molecular Formula	C15H27N5O6
Molecular Weight	373.40
XLogP	-4.6
Topological Polar Surface Area	194
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Heavy Atom Count	26
Formal Charge	0
Complexity	551

SMILES

C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)O)N

InChI

InChI=1S/C15H27N5O6/c1-7(2)12(15(25)26)20-11(22)6-18-14(24)9(4-5-10(17)21)19-13(23)8(3)16/h7-9,12H,4-6,16H2,1-3H3,(H2,17,21)(H,18,24)(H,19,23)(H,20,22)(H,25,26)/t8-,9-,12-/m0/s1

InChIKey

DXRXYJYFADHAPA-AUTRQRHGSA-N

Chemical Structure

2D Structure

CAS: 503844-09-5

CID: 10133920

Formula: C15H27N5O6

MW: 373.40

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	373.40
XLogP3	-4.6
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Exact Mass	373.19613360
Monoisotopic Mass	373.19613360
Topological Polar Surface Area	194 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	551
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-117473	DAT-230
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HY-110138-01	PDP-EA
HY-179440	EA-C15
HY-106661	GLY-230
HY-169350	EA-B2L
HY-12213-01	CDDO-EA
HY-165426	HB-230
HY-W1008866	CRBN ligand-230

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GTR19030187-01	EA-230
T70527-01	DAT-230
110077	Hsp-230
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T201739-01	EA-89
ARI0221	EA.hy926
BUP13037-01	PDP-EA
GTR19274115-01	EA-C15
GTR17968536	Ea Antibody
412677	PGE2-EA

EA-230

Chemical Information

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