EA-C15

• Description:

  EA-C15 is a potent and selective TEAD inhibitor with an IC50 of 0.34 μM. EA-C15 covalently binds to the TEAD palmitoylation site, blocks palmitoylation and transcriptional activity, and inhibits YAP-dependent cancer cell proliferation and YAP-TEAD target gene (CTGF and CYR61) transcription. EA-C15 can be used for cancer research[1].

• UNSPSC:

  12352005

• Target:

  YAP

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  C=CC(NC1=CC=C(C(C2CCCCC2)=O)C=C1C3=CC=NN3C)=O

• Molecular Formula:

  C20H23N3O2

• Molecular Weight:

  337.42

• References & Citations:

  [1]Chen W, et al. Discovery of repurposed ethacrynic acid and its derivatives as novel TEAD inhibitors. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118299.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TEAD