CDDO-EA

• Product Name Alternative:

  CDDO ethyl amide; TP319; RTA 405

• UNSPSC Description:

  CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

• Target Antigen:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CDDO-EA.html

• Purity:

  99.71

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 80°C)

• Smiles:

  O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@@]5([H])[C@@](CCC(C)(C)C5)(C(NCC)=O)CC3)(C)C2=CC4=O)([H])C1(C)C

• Molecular Weight:

  518.73

• References & Citations:

  [1]Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51(1):88-96.|[2]Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  932730-51-3