CDDO-EA

• Description :

  CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

• Product Name Alternative :

  CDDO ethyl amide; TP319; RTA 405

• UNSPSC :

  12352211

• Target :

  Keap1-Nrf2

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/CDDO-EA.html

• Concentration :

  10mM

• Purity :

  99.78

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@@]5([H])[C@@](CCC(C)(C)C5)(C(NCC)=O)CC3)(C)C2=CC4=O)([H])C1(C)C

• Molecular Formula :

  C33H46N2O3

• Molecular Weight :

  518.73

• References & Citations :

  [1]Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51 (1) :88-96.|[2]Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67 (6) :2414-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [932730-51-3]