CDDO-EA

• Description:

  CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

• Product Name Alternative:

  CDDO ethyl amide; TP319; RTA 405

• UNSPSC:

  12352211

• Target:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CDDO-EA.html

• Concentration:

  10mM

• Purity:

  99.78

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O=C1C (C#N) =C[C@@]2 (C) [C@] (CC[C@] ([C@@]3 (C) [C@@]4 ([H]) [C@@]5 ([H]) [C@@] (CCC (C) (C) C5) (C (NCC) =O) CC3) (C) C2=CC4=O) ([H]) C1 (C) C

• Molecular Formula:

  C33H46N2O3

• Molecular Weight:

  518.73

• References & Citations:

  [1]Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51 (1) :88-96.|[2]Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67 (6) :2414-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  932730-51-3