EA-B2L

• Description :

  EA-B2L is a potent degrader of glutathione S-transferase (GSTP), with the DC50 of 48 μM. EA-B2L is a kind of Boc2Lys-linked Ethacrynic acid (HY-B1640) . EA-B2L plays an important role in cancer research[1].

• UNSPSC :

  12352211

• Target :

  Glutathione S-transferase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ea-b2l.html

• Smiles :

  CCC(C(C1=C(C(Cl)=C(C=C1)OCC(NCCCCCCNC([C@H](CCCCNC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)=O)=O)Cl)=O)=C

• Molecular Formula :

  C35H54Cl2N4O8

• Molecular Weight :

  729.73

• References & Citations :

  [1]Hui Sun, et al. Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders. ACS Med Chem Lett. 2024 Oct 14;15 (11) :1852-1859

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1354444-72-6]