DAT-230

CAT: 0931-MF-0144895-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0144895-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1504583-00-9
Target
Apoptosis|||Others|||Microtubule Associated
Related Pathways
Others|||Cytoskeletal Signaling|||Apoptosis
Bioactivity
DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated with DAT-230. Apoptosis induced by DAT-230 was related with the activation of caspase-9, caspase-3 and PARP cleavage, which were at the downstream of mitochondria.
Smiles
O(C)C=1C=C(C2=C(C=CS2)C3=CC(N)=C(OC)C=C3)C=C(C)C1C
Molecular Formula
C20H21NO2S
Molecular Weight
339.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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