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DAT-230

CAT: 0931-T70527-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70527-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1504583-00-9
Target
Apoptosis, Others, Microtubule Associated
Related Pathways
Others, Cytoskeletal Signaling, Apoptosis
Bioactivity
DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated with DAT-230. Apoptosis induced by DAT-230 was related with the activation of caspase-9, caspase-3 and PARP cleavage, which were at the downstream of mitochondria.
Smiles
O(C)C=1C=C(C2=C(C=CS2)C3=CC(N)=C(OC)C=C3)C=C(C)C1C
Molecular Formula
C20H21NO2S
Molecular Weight
339.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

CID 154732123
CAS Number1504583-00-9
PubChem CID154732123
IUPAC Name2-methoxy-5-[2-(3-methoxy-4,5-dimethylphenyl)thiophen-3-yl]aniline
Molecular FormulaC20H21NO2S
Molecular Weight339.5
XLogP4.9
Topological Polar Surface Area72.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity407
SMILES
CC1=CC(=CC(=C1C)OC)C2=C(C=CS2)C3=CC(=C(C=C3)OC)N
InChI
InChI=1S/C20H21NO2S/c1-12-9-15(11-19(23-4)13(12)2)20-16(7-8-24-20)14-5-6-18(22-3)17(21)10-14/h5-11H,21H2,1-4H3
InChIKey
NPXKFXXMFDKVTM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 154732123
CAS: 1504583-00-9
CID: 154732123
Formula: C20H21NO2S
MW: 339.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight339.5
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass339.12930009
Monoisotopic Mass339.12930009
Topological Polar Surface Area72.7 Ų
Heavy Atom Count24
Formal Charge0
Complexity407
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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