DAT-230

• Target:

  Apoptosis|||Others|||Microtubule Associated

• Related Pathways:

  Others|||Cytoskeletal Signaling|||Apoptosis

• Bioactivity:

  DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated with DAT-230. Apoptosis induced by DAT-230 was related with the activation of caspase-9, caspase-3 and PARP cleavage, which were at the downstream of mitochondria.

• Smiles:

  O(C)C=1C=C(C2=C(C=CS2)C3=CC(N)=C(OC)C=C3)C=C(C)C1C

• Molecular Formula:

  C20H21NO2S

• Molecular Weight:

  339.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1504583-00-9