PROTAC SMARCA2/4-degrader-28

• UNSPSC Description:

  PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a PROTAC-based partial degrader of SMARCA2 and SMARCA4(Bliue: CRL2VHL ligand (S,R,S)-AHPC (HY-125845); Black: linker (HY-159680); Pink: a SMARCA-BD ligand (+)-JQ-1 (HY-13030))[1].

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-4-degrader-28.html

• Smiles:

  CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N[C@@H]4COCCOCCOC5=CC(C6=C(N=CS6)C)=CC=C5CNC([C@@]7([H])N(C[C@@H](C7)O)C([C@@H](NC(COCCOCCOC4)=O)C(C)(C)C)=O)=O)=O)C8=NN=C(C)N28

• Molecular Weight:

  1118.75

• References & Citations:

  [1]Angus D Cowan, et al. Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory. Annu Rev Biochem. 2022 Jun 21:91:295-319.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2409844-88-6