Products for Research Use Only
RegisterLogin

YM-344031

CAT: 0804-HY-160998Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-160998Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
YM-344031 is an orally active antagonist for CCR3. YM-344031 inhibits binding of Eotaxin-1 and RANTES to CCR3, with IC50 of 3.0 and 16.3 nM. YM-344031 inhibits ligand-induced rise in intracellular Ca[2+] and the ligand-induced chemotaxis. YM-344031 inhibits eotaxin-1-induced changes in eosinophil morphology in macaques blood, and prevents allergic skin reactions in a mouse allergy model[1].
CAS Number
671204-98-1
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ym-344031.html
Smiles
FC(C=C1)=CC(C=C2)=C1C=C2CN3C[C@@H](CC3)NC(/C=C4CCN(CC/4)C(C5=C(C=CC=[N+]5[O-])C)=O)=O
Molecular Formula
C29H31FN4O3
Molecular Weight
502.58
References & Citations
[1]Suzuki K, et al., In vitro and in vivo characterization of a novel CCR3 antagonist, YM-344031. Biochem Biophys Res Commun. 2006 Jan 27;339 (4) :1217-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR3

Related Products

CatalogName
HY-19115YM-430
HY-101833-01YM-264
HY-111557-01YM-254890
HY-U00104-01YM-46303
HY-100724YM-17690
HY-N5208YM-216391
HY-111296-01YM 53403
HY-122157YM-534
HY-106896YM 934
HY-139144-01YM-08

Alternative Products

CatalogName
T88324-01YM-344031
C21722-100uLYm-1 + Ym-2 Antibody [C18B8]
M34742-01YM 534
SD7031YM Medium
BA6789-5YM-244769
BA4193-5YM-1
B7399-25YM 202074
B5637-10YM 244769
B6825-50YM 90709
B6870-10YM 976

Popular Products