YM-08

• Description :

  YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2, with the IC50 of 19.9 μM. YM-08 also is inhibitor of Hsp70[1].

• UNSPSC :

  12352005

• Target :

  HSP; Sirtuin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ym-08.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(CC)/C(S/C1=C2SC3=CC=CC=C3N/2C)=C\C4=NC=CC=C4

• Molecular Formula :

  C19H17N3OS2

• Molecular Weight :

  367.49

• References & Citations :

  [1]Abbotto E, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel) . 2023;16 (9) :1316. Published 2023 Sep 18.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP70

• CAS Number :

  [812647-88-4]