YM-08

CAT: 0804-HY-139144-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-139144-01Size:5 mg
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Description
YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2, with the IC50 of 19.9 μM. YM-08 also is inhibitor of Hsp70[1].
CAS Number
[812647-88-4]
UNSPSC
12352005
Target
HSP; Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ym-08.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CC)/C(S/C1=C2SC3=CC=CC=C3N/2C)=C\C4=NC=CC=C4
Molecular Formula
C19H17N3OS2
Molecular Weight
367.49
References & Citations
[1]Abbotto E, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel) . 2023;16 (9) :1316. Published 2023 Sep 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70

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