YM-46303

• Description :

  YM-46303 is an mAChR antagonist which exhibits the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor.

• UNSPSC :

  12352005

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/YM-46303.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(OC12CCN(CC2)CC1)NC3=CC=CC=C3C4=CC=CC=C4.[H]Cl

• Molecular Formula :

  C20H23ClN2O2

• Molecular Weight :

  358.86

• References & Citations :

  [1]Naito R, et al. Selective muscarinic antagonists. II. Synthesis and antimuscarinic properties of biphenylylcarbamate derivatives. Chem Pharm Bull (Tokyo) . 1998 Aug;46 (8) :1286-94.|[2]Nagashima S, et al. Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists. Bioorg Med Chem. 2014 Jul 1;22 (13) :3478-87.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAChR1

• CAS Number :

  [171722-81-9]