YM-344031

• Target:

  CCR

• Related Pathways:

  Immunology/Inflammation|||Microbiology/Virology|||GPCR/G Protein

• Bioactivity:

  YM-344031 is an orally administered antagonist targeting CCR3. It effectively inhibits the binding of Eotaxin-1 and RANTES to CCR3, with IC50 values of 3.0 and 16.3 nM, respectively. YM-344031 also suppresses ligand-induced increases in intracellular Ca [2+] levels and chemotaxis, alters eosinophil morphology induced by eotaxin-1 in macaque blood, and prevents allergic skin reactions in a mouse allergy model.

• Smiles:

  C(C1=CC2=C(C=C1)C=C(F)C=C2)N3C[C@H](NC(C=C4CCN(C(=O)C5=C(C)C=CC=N5=O)CC4)=O)CC3

• Molecular Formula:

  C29H31FN4O3

• Molecular Weight:

  502.58

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  671204-98-1