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YM-344031

CAT: 0931-T88324-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88324-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
671204-98-1
Target
CCR
Related Pathways
Immunology/Inflammation, Microbiology/Virology, GPCR/G Protein
Bioactivity
YM-344031 is an orally administered antagonist targeting CCR3. It effectively inhibits the binding of Eotaxin-1 and RANTES to CCR3, with IC50 values of 3.0 and 16.3 nM, respectively. YM-344031 also suppresses ligand-induced increases in intracellular Ca [2+] levels and chemotaxis, alters eosinophil morphology induced by eotaxin-1 in macaque blood, and prevents allergic skin reactions in a mouse allergy model.
Smiles
C(C1=CC2=C(C=C1)C=C(F)C=C2)N3C[C@H](NC(C=C4CCN(C(=O)C5=C(C)C=CC=N5=O)CC4)=O)CC3
Molecular Formula
C29H31FN4O3
Molecular Weight
502.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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