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AR-9281

CAT: 0804-HY-111151-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111151-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes[1][2].
CAS Number
913548-29-5
Product Name Alternative
APAU
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ar-9281.html
Purity
99.69
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1(C2)CC3CC2CC(C3)C1)NC4CCN(C(C)=O)CC4
Molecular Formula
C18H29N3O2
Molecular Weight
319.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Fangyu Du, et al. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. Eur J Med Chem. 2021 Nov 5;223:113678. |[2]Kathleen Guglielmino, et al. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012 Oct 1;303 (7) :H853-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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