Psa-AR

• Description:

  Psa-AR is a PROTAC degrader targeting PSMA. Psa-AR exhibits potent degradation ability of AR, AR-V7, and HSP90, and induces cell apoptosis. Psa-AR can be used for cancer research[1]. (Pink: PSMA Ligand (HY-179051) ; Blue: CRBN Ligand (HY-131717) ; Black: Linker)

• UNSPSC:

  12352005

• Target:

  Androgen Receptor; Apoptosis; HSP; PROTACs; PSMA

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; PROTAC; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Smiles:

  OC(C(CCCCNC(C(NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CCC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CCC(N)=O)NC([C@@H](CS)NC([C@H](CCCCNC(C(C=C4)=C(F)C=C4N5C(N(C(C5(C)C)=O)C6=CC=C(C#N)C(C(F)(F)F)=C6)=S)=O)NC(CNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC%10=CC=C%11C(C=CC=C%11)=C%10)=O)NC(NC(CCC(O)=O)C(O)=O)=O)=O

• Molecular Formula:

  C110H120F4N22O29S2

• Molecular Weight:

  2354.38

• References & Citations:

  [1]Yang FY, et al. In vivo self-assembled nano-PROTAC for the dual degradation of AR and HSP90 to overcome castration-resistant prostate cancer resistance. Signal Transduct Target Ther. 2025 Oct 15;10 (1) :346.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon; HSP90