AR-C141990

• Description:

  AR-C141990 (Compound 30) is a potent blocker of the monocarboxylate transporter MCT1 with a Ki of 4.8 nM. AR-C141990 (Compound 30) inhibits CYP3A4 and CYP2C9 with IC50 values of 16 μM[1].

• UNSPSC:

  12352005

• Target:

  Cytochrome P450; Monocarboxylate Transporter

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ar-c141990.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(CC(C)C)C2=C(C(C(N3C[C@H](O)CC3)=O)=C(CC4=CC=NC5=CC=CC=C45)S2)C(N1C)=O

• Molecular Formula:

  C26H28N4O4S

• Molecular Weight:

  492.59

• References & Citations:

  [1]Guile SD, et al. Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds. Bioorg Med Chem Lett. 2006 Apr 15;16 (8) :2260-5.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [873327-59-4]