AR-A 2

• Description:

  AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety.

• Product Name Alternative:

  AR-A 000002

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/AR-A_2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC=C(N2CCN(C)CC2)C3=C1CC[C@@H](NC(C4=CC=C(N5CCOCC5)C=C4)=O)C3

• Molecular Formula:

  C27H36N4O2

• Molecular Weight:

  448.60

• References & Citations:

  [1]Ahlgren C, et al. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine (1B) autoreceptor antagonist. Eur J Pharmacol. 2004 Sep 19;499 (1-2) :67-75.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor; mLAG-3; α-1 microglobulin

• CAS Number:

  [220051-79-6]