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AR-A 2

CAT: 0804-HY-107018Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107018Size:1 Each
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Description
AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety.
CAS Number
220051-79-6
Product Name Alternative
AR-A 000002
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AR-A_2.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(N2CCN(C)CC2)C3=C1CC[C@@H](NC(C4=CC=C(N5CCOCC5)C=C4)=O)C3
Molecular Formula
C27H36N4O2
Molecular Weight
448.60
References & Citations
[1]Ahlgren C, et al. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine (1B) autoreceptor antagonist. Eur J Pharmacol. 2004 Sep 19;499 (1-2) :67-75.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3; α-1 microglobulin

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