AR/AR-V7-IN-1

AR/AR-V7-IN-1

• CAS Number: 2964558-54-9
• UNSPSC Description: AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC50 = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth with IC50 values of 4.87 and 2.07 μM in the LNCaP and 22RV1 cell lines, respectively. AR/AR-V7-IN-1 exhibits effective tumor growth inhibition in the 22RV1 xenograft study. AR/AR-V7-IN-1 can be used for the research of prostate cancer[1].
• Target Antigen: Androgen Receptor
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ar-ar-v7-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: FCCCN(C1)CC1NC2=CC=C(C=C2)CC3CCN(C4=CC=C(N=N4)C(N[C@@H]5CC[C@H](CC5)OC6=CC(Cl)=C(C=C6)C#N)=O)CC3
• Molecular Weight: 660.22
• References & Citations: [1]Yang Y, et al. Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer. Eur J Med Chem. 2024 Apr 15;271:116400.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported