FLT3/D835Y-IN-1

FLT3/D835Y-IN-1

• CAS Number: 2648799-49-7
• UNSPSC Description: FLT3/D835Y-IN-1 (compound 13a) is a orally active, potent and selective FLT3 and FLT3/D835Y inhibitor, with IC50 values of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 also blocks tumor growth, has anticancer efficacy, and can be used to research for AML (acute myeloid leukemia)[1].
• Target Antigen: FLT3
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/flt3-d835y-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC2=C(C=CC=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OCC(N5CCNCC5)=O
• Molecular Weight: 403.43
• References & Citations: [1]Lee JH, Shin JE, Kim W, et al. Discovery of indirubin-3'-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia. Eur J Med Chem. 2022 Apr 21;237:114356.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported