BMS-707035

• Description :

  BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI) . BMS-707035 has enzyme inhibitory with an IC50 value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  HIV; HIV Integrase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/BMS-707035.html

• Purity :

  99.99

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  FC1=CC=C(C=C1)CNC(C(N=C(N2C)N3S(CCCC3)(=O)=O)=C(C2=O)O)=O

• Molecular Formula :

  C17H19FN4O5S

• Molecular Weight :

  410.42

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]B Narasimhulu Naidu, et al. The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor. Bioorg Med Chem Lett. 2018 Jul 1;28 (12) :2124-2130.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HIV-1

• CAS Number :

  [729607-74-3]