RN-1747

• Description :

  RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H319

• Target :

  TRP Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/rn-1747.html

• Concentration :

  10mM

• Purity :

  99.27

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=S(N1CCN(CC2=CC=CC=C2)CC1)(C3=CC=C(Cl)C=C3[N+]([O-])=O)=O

• Molecular Formula :

  C17H18ClN3O4S

• Molecular Weight :

  395.86

• Precautions :

  H319

• References & Citations :

  [1]Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389 (3) :490-4.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TRPM8; TRPV4

• CAS Number :

  [1024448-59-6]