Products for Research Use Only
RegisterLogin

UK-1745

CAT: 0804-HY-117181Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-117181Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
UK-1745 is a cardiotonic agent with vasodilating and antiarrhythmic properties. It increases intracellular levels of cyclic adenosine monophosphate (cAMP) in cardiomyocytes by inhibiting phosphodiesterase III, thereby enhancing myocardial contractility. Additionally, UK-1745 exhibits β-adrenergic receptor blocking activity, which helps reduce the oxygen consumption of the heart and prevent calcium overload. These characteristics make UK-1745 a promising candidate for research in congestive heart failure[1][2].
CAS Number
170684-14-7
UNSPSC
12352005
Target
Adrenergic Receptor; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/uk-1745.html
Smiles
CC1(C2=C(NC1=O)C(C)=CC3=C2O[C@](CN)(C)[C@H]3C)C.Cl
Molecular Formula
C16H23ClN2O2
Molecular Weight
310.82
References & Citations
[1]Sawada, et al. "Pharmacological Characterization of Effects of UK-1745, a Novel Cardiotonic Agent withβ-Adrenoceptor-blocking Action, in Aequorin-loaded Canine Right Ventricular Muscle." Journal of molecular and cellular cardiology 31.5 (1999) : 1047-1062.|[2]Uchida, et al. "Cardiovascular effects of (2RS, 3SR) -2-aminomethyl-2, 3, 7, 8-tetrahydro-2, 3, 5, 8, 8-pentamethyl-6H-furo-[2, 3-e] indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties." Arzneimittel-forschung 48.3 (1998) : 219-231.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-111084UK 52831
HY-19391UK-240455
HY-101214-01UK-371804
HY-123150UK-447841
HY-108982UK 55444
HY-108200UK-315716
HY-105341UK 343664
HY-13102-01UK-383367
HY-123421UK-9040
HY-118148-01UK-66914

Alternative Products

CatalogName
GTR19192503UK 1745
GTR19195463Bam 1745
A4440-10UK 356618
A3899-10UK-5099
462157UK 370106
T69294-01UK-396082
T34990-01UK 39671
T29049-01UK-432097
T29050-01UK 66914
022640UK-356618

Popular Products