RN-9893

• Description :

  RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively[1].

• UNSPSC :

  12352005

• Target :

  TRP Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/rn-9893.html

• Purity :

  99.91

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=S(C(C=C1)=CC=C1NC(C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2)=O)(N3CCN(C(C)C)CC3)=O

• Molecular Formula :

  C21H23F3N4O5S

• Molecular Weight :

  500.49

• References & Citations :

  [1]Wei ZL, et, al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett. 2015 Sep 15;25 (18) :4011-5.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1803003-68-0]