ARL 17477

• Description :

  ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H319

• Target :

  NO Synthase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/arl-17477.html

• Purity :

  99.02

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

• Smiles :

  [H]Cl.[H]Cl.N=C(C1=CC=CS1)NC2=CC=C(CCNCC3=CC(Cl)=CC=C3)C=C2

• Molecular Formula :

  C20H22Cl3N3S

• Molecular Weight :

  442.83

• Precautions :

  H302, H319

• References & Citations :

  [1]Teiko Komori Nomura, et al. ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo. Sci Rep. 2023 Jul 4;13 (1) :10757.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [866914-87-6]