AX-9657

CAT: 0804-HY-11046Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-11046Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
KRP-109 is a neutrophil elastase (NE) inhibitor with activity in reducing lung inflammation. KRP-109 improves survival in mouse models and reduces the number of neutrophils and inflammation in the alveolar walls. KRP-109 significantly reduced cell and neutrophil counts in bronchoalveolar lavage fluid, as well as cytokine levels such as interleukin 1β and macrophage inflammatory protein 2. KRP-109 can be used in the research of severe pneumonia[1].
CAS Number
[1015439-77-6]
UNSPSC
12352005
Target
Elastase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C1OC(C2=CC=CN=C2N3C[C@@H](N(C)C)CC3)=NC4=CC(OC)=CC(CC)=C14
Molecular Formula
C22H26N4O3
Molecular Weight
394.47
References & Citations
[1]Yamada K, et al. In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia. Pulm Pharmacol Ther. 2011 Dec;24 (6) :660-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-101846-01AX-15836
HY-P991363-01AX-202
HY-172761AX-53802
HY-107390-01AX-024
HY-107390A-01AX-024 (hydrochloride)
HY-179505OPN-9652

Alternative Products

CatalogName
MBS3844485-01AX-15836
MBS5803782AX-024
TRC-A965385-100MGAX 15836
C01316AX 20017
AX-20341BioLyse AX
AX-10332BioDil AX
MF-0063777-01AX-7396
MF-0047539-01AX 048
MF-0063776-01AX-53802

Popular Products