AX-9657

• Description :

  KRP-109 is a neutrophil elastase (NE) inhibitor with activity in reducing lung inflammation. KRP-109 improves survival in mouse models and reduces the number of neutrophils and inflammation in the alveolar walls. KRP-109 significantly reduced cell and neutrophil counts in bronchoalveolar lavage fluid, as well as cytokine levels such as interleukin 1β and macrophage inflammatory protein 2. KRP-109 can be used in the research of severe pneumonia[1].

• UNSPSC :

  12352005

• Target :

  Elastase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C1OC(C2=CC=CN=C2N3C[C@@H](N(C)C)CC3)=NC4=CC(OC)=CC(CC)=C14

• Molecular Formula :

  C22H26N4O3

• Molecular Weight :

  394.47

• References & Citations :

  [1]Yamada K, et al. In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia. Pulm Pharmacol Ther. 2011 Dec;24 (6) :660-5.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1015439-77-6]