HDAC-IN-43

CAT: 0931-T62545-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T62545-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1809163-24-3

Target

Others, PI3K, mTOR, HDAC

Related Pathways

PI3K/Akt/mTOR signaling, Others, Chromatin/Epigenetic, DNA Damage/DNA Repair

Bioactivity

HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82 nM for HDAC 1, 45 nM for HDAC 3, and 24 nM for HDAC 6, and a weak PI3K/mTOR inhibitor with IC50 values of 3.6 μM for PI3K and 3.7 μM for mTOR, exhibiting a broad-spectrum anti-proliferative effect.

Smiles

C(C)(C)N1C=2C(=C(N=C(N2)N3CCOCC3)C4=CC(OCCCC(NO)=O)=CC=C4)N=C1

Molecular Formula

C22H28N6O4

Molecular Weight

440.5

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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