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Mt KARI-IN-4

CAT: 0931-T61395-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61395-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2413974-53-3
Target
Others, Antibacterial
Related Pathways
Others, Microbiology/Virology
Bioactivity
Mt KARI-IN-4 (compound 5c) is a highly effective inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), with a Ki of 5.48 μM. It also inhibits Mtb H37Rv, displaying a minimum inhibitory concentration (MIC) of 0.78 μM, and exhibits low cytotoxicity, with an IC50 over 72 μg/mL against human embryonic kidney cells (HEK) [1].
Smiles
N(C(NC1=CC=C(F)C=C1)=S)C=2SC(=NN2)C=3OC(N(=O)=O)=CC3
Molecular Formula
C13H8FN5O3S2
Molecular Weight
365.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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GTR19263463-01KARI 201 hydrochloride
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