TK-129

CAT: 0931-T60713-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0931-T60713-01Size:50 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others|||Histone Demethylase
Related Pathways
Others|||Chromatin/Epigenetic
Bioactivity
TK-129 is an orally active, potent inhibitor of KDM5B with an IC50 of 44 nM and is low-toxicity. TK-129 exhibits cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 can be used in cardiovascular disease studies to reduce isoprenaline-induced myocardial remodelling and fibrosis in vivo, as well as to reduce ang II-induced activation of cardiac fibroblasts in vitro [1].
Molecular Formula
C15H23N5O2
Molecular Weight
305.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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