TK-129

• Target :

  Others|||Histone Demethylase

• Related Pathways :

  Others|||Chromatin/Epigenetic

• Bioactivity :

  TK-129 is an orally active, potent inhibitor of KDM5B with an IC50 of 44 nM and is low-toxicity. TK-129 exhibits cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 can be used in cardiovascular disease studies to reduce isoprenaline-induced myocardial remodelling and fibrosis in vivo, as well as to reduce ang II-induced activation of cardiac fibroblasts in vitro [1].

• Molecular Formula :

  C15H23N5O2

• Molecular Weight :

  305.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C