TK-685

• Description:

  TK-685 is an orally active, selective, and allosteric SHP2 inhibitor with an IC50 of 2.1 nM. TK-685 inhibits esophageal cancer cell proliferation and induced apoptosis by targeting SHP2-mediated AKT and ERK signaling pathways[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; SHP2

• Related Pathways:

  Apoptosis; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  ClC1=C(C=CC=C1SC2=NNC(N=C(N3)N4CCC(C)(CC4)CN)=C2C3=O)Cl

• Molecular Formula:

  C18H20Cl2N6OS

• Molecular Weight:

  439.36

• References & Citations:

  [1]Song Y, et al. Structure-Guided Design of Pyrazolopyrimidinones as Highly Potent and Selective Allosteric SHP2 Inhibitors. J Med Chem. 2025 Apr 16.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported