TK-685

CAT: 0804-HY-173571Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-173571Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TK-685 is an orally active, selective, and allosteric SHP2 inhibitor with an IC50 of 2.1 nM. TK-685 inhibits esophageal cancer cell proliferation and induced apoptosis by targeting SHP2-mediated AKT and ERK signaling pathways[1].
UNSPSC
12352005
Target
Apoptosis; SHP2
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
ClC1=C(C=CC=C1SC2=NNC(N=C(N3)N4CCC(C)(CC4)CN)=C2C3=O)Cl
Molecular Formula
C18H20Cl2N6OS
Molecular Weight
439.36
References & Citations
[1]Song Y, et al. Structure-Guided Design of Pyrazolopyrimidinones as Highly Potent and Selective Allosteric SHP2 Inhibitors. J Med Chem. 2025 Apr 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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